With advances in technology, we are discovering new tick-borne disease (TBD) agents and have more tests available to us than ever. It is getting harder to know which patients to test, which tests to run, what to do with the results, and how to communicate this to our clients. We will review some indications for testing sick dogs, discuss the benefits of screening healthy dogs for exposure to or infection with TBD agents, and explain how to provide this information to pet owners.